Short-acting GLP-1RAs (exenatide [ t 1/2 of 2.4 hours] and lixisenatide [ t 1/2 of 24 hours] administered before meals twice-daily and once-daily, respectively) exhibit intermittent GLP-1 receptor activation translating into potent deceleration of upper gastrointestinal motility, an effect which is sustained during prolonged treatment
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Li QX, Gao H, Guo YX et al (2021) GLP-1 and underlying beneficial actions in alzheimers disease, hypertension, and NASH
Here are common signs of a plateau: No weight change on the scale for weeks Difficulty reducing body measurements Clothes fit the same despite effort Plateaus are a normal part of weight loss and affect many people
U.RosenkildeM.et al (2020)
Higher drug concentrations mean stronger glucose-lowering effects